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Cronhs Disease

What is Crohn’s disease?Crohn’s disease is a disease of the gastrointestinal (GI) system involving intestinal wall inflammation. Any part of the GI system, from mouth to anus, can be affected.This condition affects about one in 1500 to 3000 people. It can happen at any age and usually begins at the age of 15 to 30 years. It affects females slightly more often than males. The incidence of Crohn’s is increasing all over the world as well as in India.

Which part of the GI system is affected by Crohn’s disease? The most common site where the disease spreads most is the ileum, the last part of the small intestine. The colon is the second most common site to get affected.Inflammation’s patch may be small or widespread. Multiple patches of inflammation may also appear in non-inflamed areas of the gut.

What causes Crohn’s disease?The exact cause of Crohn’s disease is unknown. There are different theories laid to explain the cause:
  • Genetic factors – close relatives suffer from this condition, indicating a role of the genes in its occurrence.
  • Germ theory – bacteria or viruses can also be involved. The attack of bacteria or viruses triggers the immune system to evoke gut inflammation.
  • Smoking – smokers are affected more than non-smokers.
What are the signs and symptoms of Crohn’s disease?The symptoms are seen during a flare-up of the disease due to inflammation in the wall of the affected parts of the GI tract. One or more of the following clinical features can be seen:
  • Pain at the affected site – It may occur in about 7 in 10 cases. The most common site of the pain is the lower right side of the abdomen. Sometimes Crohn’s disease mimics appendicitis. The pain severity varies from person to person.
  • Diarrhoea is the first symptom observed in most cases. It can be mild or severe. The stool contains mucus, pus or blood. Tenesmus (fruitless urge for bowel movement) can be seen.
  • Unintentional weight loss is another common symptom.
  • Blood in the stool can be observed due to ulcers of the gut lining.
  • Anaemia is another consequence due to bleeding.
  • A general feeling of unwellness with tiredness, fever, and loss of appetite may be observed.
  • Mouth ulcers are not uncommon.
  • Anal fissures (painful ‘cracks’ around the anus) may occur. Small wart-like lumps (skin tags) may also appear around the anal area.
How does it progress?Crohn’s disease is a chronic condition which means that it is a long-term condition. Sometimes there may be few or no symptoms, known as remission. However, it can relapse after some time as a flare-up. The frequency and severity of symptoms vary from person to person. Most often, the first symptoms or first episode are the worst.

What are the complications of Crohn’s disease?Several complications can arise and often need treatment with surgery.
  • Stricture, which means narrowing the gut, can be seen due to scar tissue formation. Stricture may cause vomiting with pain as it obstructs the passage of food.
  • Perforation (a small hole) can form in the gut wall through which the gut’s contents can leak out. It may further cause an abscess or infection inside the abdomen. This condition can be life-threatening.
  • Fistulas can also occur. A fistula is an abnormal opening between two parts of the body.
  • Crohn’s disease carries a small increased risk of colon cancer.
  • Osteoporosis (bones’ thinning) may be seen due to poor absorption of calcium and vitamin D.
What are the tests to diagnose Crohn’s disease?The tests which help in the diagnosis and determining the disease severity are the following:
  • Colonoscopy or gastroscopy, where the gastroenterologist will look inside the colon, ileum, and stomach using a flexible endoscope.
  • MRI or CT scan, which may be needed if the diagnosis is in doubt.
  • Blood test to assess the level of inflammation within the gut, to assess your general wellbeing, and to check for anaemia and other deficiencies.
How is it treated?The treatment approach is based on various factors like the severity of symptoms and their association with other symptoms. The decision of treatment can be complex. The multiple options for treatment are the following:
  • Wait and watch – No treatment is needed when the symptoms are very mild. Some symptoms may settle down on their own.
  • Use of steroids (corticosteroids) – to treat any flare-ups. Steroids are discontinued once a flare-up has settled.
  • Antibiotics – They are used if infective complications are suspected.
  • Immunosuppressant drugs – They are used to suppress the immune system. These drugs have significantly impacted the treatment of Crohn’s disease.
  • Aminosalicylate drugs – They are thought to counter inflammation in Crohn’s disease. These are used rarely. These drugs come in different brand names and preparations, such as sachets or suspension, oral tablets or suppositories, and liquid or foam enemas. Depending on the site of the inflammation in the gut, the type of preparation is chosen.
  • Surgery- If other treatments do not work. Surgery is also used when there is a complication like chronic fistulas, strictures, and abscesses.
  • Dietary treatments – These are elemental diets that involve a liquid diet containing essential proteins and other nutrients. They are beneficial in some cases. They are mainly used in children. The diet can settle down a flare-up in four weeks, and a regular diet is started gradually after that. An elemental diet may be an alternative for people whose medication has not worked well or has caused harmful side effects.
  • Supplements – Increased folate supplements and certain drugs are needed if Crohn’s disease happens during pregnancy.
Summary : Crohn’s disease is a chronic disease with a range of digestive symptoms that sometimes may become life-threatening. Timely management is much needed here.Various treatments are available, and a gastroenterologist, after discussion with the patient, selects one which suits best. New drugs and therapies are evolving, giving a positive ray of hope.
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